Melatonin rescues the age-induced alteration in rhythmic clock gene and clock-controlled gene expression in rat hippocampus
Ratchadaporn Pramong, Cheng Nilbu-nga, Pansiri Phansuwan-Pujito · FENS Forum 2024
Aging has potent effects on many basic parameters of circadian rhythm and also are associated with impairments in learning and memory. Melatonin, a hormone mainly secreted in the pineal gland, is believed to restore circadian rhythm of clock genes in the suprachiasmatic nucleus during aging. The present study attempted to examine the daily profiles of different clock genes, and the clock-controlled cognition-related gene during development and aging and examine the effect of melatonin on the expression of these genes during aging in rat hippocampus. The results showed that the mRNA of the cloc
ePoster · Neuroscience