Topic: membrane depolarization

Epilepsy is a chronic neurological disorder characterized by recurrent seizures resulting from abnormal electrical activity in the brain. All experimental models for seizure generation are based on the administration of drugs (e.g. pilocarpine), on artificial increase in the concentrations of extracellular K+ (Ko) or on direct electric stimulation, to name a few. However, all these approaches may not accurately reflect the in vivo conditions, where otherwise normal neuronal activity can generate occasional seizures. It is thus important to better understand the pathological changes that may be