Topic: memory deficit

Adinazolam (ADZ) is one of the benzodiazepine-type new psychoactive substances (NPSs) with anxiolytic, anticonvulsant, and antidepressant effects. Although it is previously reported that high dose of ADZ administration impaired psychomotor performance and memory, abuse potential and drug dependence of ADZ have not been fully investigated. In this study, we evaluated whether ADZ has abuse potential, and lead in drug dependence and withdrawal symptoms when ADZ treatment was abruptly stopped. ADZ (0.01, 0.03, and 0.1 mg/kg/inf) increased intravenous self-administration in Sprague Dawley rats, sug