Submillimeter targeting of the hippocampal formation with deep brain stimulation electrodes based on high-resolution MRI-guided neuronavigation in non-human primates
Ankur Gupta, Adrien Boissenin, Nikolaos Vardalakis, Mathieu Taillade, Hugues Orignac, Tho Hai Nguyen, Amirouche Sadoun, Fabien Wagner · FENS Forum 2024
Deep Brain Stimulation (DBS) of the hippocampal formation is currently investigated as a therapeutic approach for the treatment of memory disorders and epilepsy. Although various neurostimulation protocols have been extensively studied semi-acutely in epileptic patients, their refinement requires more standardized preclinical testing in non-human primates (NHP). However, targeting deep brain structures such as the hippocampal formation in NHP still remains a challenging task. Here, we present a technological framework for submillimeter targeting of the hippocampal formation in macaque monkeys
ePoster · Neuroscience