Vangl2 participates in the correct temporal connectivity of the DG-CA3 circuits and in declarative memory processes
Noémie Depret, Maïté Moreau, Marie Gleizes, Eloise Daniel, Sonia Poirault-Chassac, Anne Quiedeville, Steve Dos-Santos-Carvalho, Alice Shaam Al Abed, Gaël Barthet, Christophe Mulle, Aline Desmedt, Aline Mariguetto, Claudia Racca, Mireille Montcouquiol, Nathalie Sans · FENS Forum 2024
Vangl2, a central protein of the Wnt/PCP pathway, is a known key player in morphogenesis. One of our recent studies also linked it to the regulation of cognitive function. However, we lack information on the precise role of Vangl2 in different types of synapses associated with specific cognitive processes. Here, we found that Vangl2 is essential for the development and function of a specific hippocampal connection, the MFB/TE synapse. We show that Vangl2 is enriched in the postnatal hippocampus, specifically in the DG and CA3. Using 3D reconstruction of confocal and SBFSEM acquisitions, we sho
ePoster · Neuroscience