Ensemble remodeling supports memory-updating
Austin Baggetta, Denise Cai, William Mau, Denisse Morales-Rodriguez, Zhe (Phil) Dong, Brian Sweis, Zachary Pennington, Taylor Francisco, Mark Baxter, Tristan Shuman · COSYNE 2023
Memory-updating is critical in dynamic environments because updating memories with new information promotes versatility. However, little is known about how memories are updated with new information. To study how neuronal ensembles might support memory-updating, we used a hippocampus-dependent spatial reversal task to measure hippocampal ensemble dynamics when mice switched navigational goals. Using Miniscope calcium imaging, we identified neuronal ensembles (co-active neurons) in dorsal CA1 that were spatially tuned and stable across training sessions. When reward locations were moved during a
Fri, Mar 10, 2023