Topic: meningeal immune system

Huntington’s disease (HD) is a hereditary neurodegenerative disorder marked by progressive motor and cognitive decline caused by a mutation in the huntingtin gene. Emerging research implicates the immune system and inflammation in HD pathogenesis. Recent investigations reveal immune cells and lymphatic networks within the meninges, challenging their conventional role solely as a protective CNS barrier. Meningeal immune cells are increasingly recognized for their role in normal brain function and various neurological disorders. However, investigations into meningeal immunity in the context of H