Topic: mesencephalon

Understanding the neurodevelopment of cerebellar nuclei (CN), the primary output of the cerebellum, is crucial. Traditionally, the rhombic lip (RL) and ventricular zone (VZ) have been known as the origins of glutamatergic excitatory and GABAergic inhibitory CN neurons, which emerge after embryonic day 9 (E9). However, our study uncovers a novel subset of cells in the nuclear transitory zone (NTZ), a transient area for future CN that appears even before E9. Our study’s objective is to map the fate of these early-appearing cells in the developing cerebellum. Utilizing SncaGFP transgenic mice, th