Depression related to early life adversity: What preclinical models can tell us?
Alice Passeri, Lucy Babicola, Camilla Mancini, Matteo Di Segni, Diana Municchi, Carlo Cifani, Rossella Ventura · FENS Forum 2024
Major Depressive Disorder (MDD) is characterized by a constellation of symptoms, summarized into three major categories: passive coping strategies, anhedonia, and social impairment.The use of animal models can help to explore these symptoms and investigate their underlying mechanisms, such as oxytocinergic and opioids alterations within the mesocorticolimbic circuit.Exposure to Early Life Adversities (ELA), including Attachment Bond Disruption and Adverse Childhood Experiences, such as Neglect, represents one of the most important risk factors for development of MMD.To model attachment disrupt
ePoster · Neuroscience