Dopamine deficient mice show anergia but not anhedonia on tests of vigor-based choice
Andrea Martinez Verdu, Adrian Sanz-Magro, Noelia Granado, Régulo Olivares-García, Paula Matas-Navarro, Nicolás Pons-Villanueva, John D. Salamone, Rosario Moratalla, Mercè Correa · FENS Forum 2024
Motivated behavior is characterized by a high degree of vigor, activity persistence, and effort. Nucleus Accumbens (Nacb) dopamine (DA) plays a major role in voluntary locomotion and in the activational component of motivated behaviors, including effort-related decision-making. The transcription factor Pitx3 is critical for the survival of mesolimbic DA neurons. Aphakia mice (Ak) have a mutation in Pitx3, which leads to a reduction in dorsal-striatal dopaminergic innervation and results in parkinsonian-like motor alterations. They also show a reduction in ventral-striatal DA, including Nacb. I
ePoster · Neuroscience