Early cortical network deficits underlying abnormal stimulus perception in Shank3b+/- mice
Elena Montagni, Manuel Ambrosone, Alessandra Martello, Daniele M. Papetti, Daniela Besozzi, Lorenzo Curti, Laura Baroncelli, Alessio Masi, Guido Mannaioni, Francesco S. Pavone, Anna L. A. Mascaro · FENS Forum 2024
Autism spectrum disorders (ASDs) are a range of neurodevelopmental disorders affecting social communication and behavior. Brain network dysfunctions are supported as a neurobiological basis for ASDs. Thus, functional connectivity (FC) studies are pivotal for unraveling autism-related large-scale network dynamics. Although functional imaging studies during development can be instrumental for autism diagnosis, longitudinal studies of FC consolidation over development to adulthood are missing in mice. SHANK3 is a postsynaptic scaffolding protein of excitatory synapses. Its deletion or mutation is
ePoster · Neuroscience