Loss of hemodynamic functional connectivity during high arousal does not reflect neuronal uncoupling
Bradley Rauscher, Natalie Fomin-Thunemann, Sreekanth Kura, Patrick Doran, Pablo D. Perez, Dora Balog, Nathan Chai, Francesca Froio, Patrick Bloniasz, Kivilcim Kılıç, John Jiang, Emily Martin, Emily Stephen, Martin Thunemann, David A. Boas, Anna Devor · FENS Forum 2024
Ascending neuromodulatory projections from deep brain nuclei generate internal brain states that differentially engage specific neuronal cell types. Because neurovascular coupling is cell-type specific and neuromodulatory transmitters have vasoactive properties, we hypothesized that the impulse response function (IRF) linking spontaneous neuronal activity with hemodynamics would depend on brain state. To test this hypothesis, we used mesoscopic optical imaging to measure (1) release of neuromodulatory transmitters norepinephrine (NE) or acetylcholine (ACh), (2) Ca2+ activity of local cortic
ePoster · Neuroscience