Alterations of specific metabolites during epileptogenesis in plasma of rats with lithium-pilocarpine-induced temporal lobe epilepsy
Fatma Merve Antmen, Emir Matpan, Ekin Dongel Dayanc, Eylem Ozge Savas, Yunus Eken, Dilan Acar, Alara Ak, Begum Ozefe, Damla Sakar, Ufuk Canozer, Sehla Nurefsan Sancak, Ozkan Ozdemir, Osman Ugur Sezerman, Ahmet Tarik Baykal, Mustafa Serteser, Guldal Suyen · FENS Forum 2024
Temporal lobe epilepsy (TLE) arises mostly due to an initial injury. Certain stimuli can make a normal brain prone to repeated, spontaneous seizures via a process called epileptogenesis. The aim of this study is to examine the plasma metabolomics profile in TLE-induced rats to find feasible biomarkers that can distinguish phases of epileptogenesis. Status epilepticus (SE) was induced by low-dose-repetitive-lithium chloride–pilocarpine hydrocholoride intraperitoneal injections. Control groups just received saline injections. Blood samples were collected 48 hours, 7 days and 6 weeks after SE, re
ePoster · Neuroscience