ePoster · Computational Neuroscience
Migraine mutation of a Na+ channel induces a switch in excitability type and energetically expensive spikes in an experimentally-constrained model of fast-spiking neurons
Leonardo Preuss, Jan-Hendrik Schleimer, Louisiane Lemaire, Susanne Schreiber · Bernstein Conference 2024
Familial hemiplegic migraine type 3 (FHM-3) is a type of migraine with aura, caused by gain-of-function mutations of NaV1.1 [1,2]. This voltage-gated channel is mainly expressed in fast-spiking inhibitory neurons as their dominant Na+ channel. Cortical spreading depolarization, a wave of hyperexcitability followed by silencing of firing, is the proposed mechanism for the generation of migraine attacks. The exact pathways driving this wave are unclear, although extracellular K+ build-up is thought to be involved in both its onset [3] and propagation. Recent direct recordings from axons of fast