A postnatal molecular switch drives the activity-dependent maturation of cortical parvalbumin interneurons
Monika Moissidis, Leyla Abbavova, Rafael Alis, Clémence Bernard, Yaiza Dominguez, Shenyue Qin, Audrey Kelly, Fazal Oozeer, Laura Modol, Fursham Hamid, Paul Lavender, Nuria Flames, Oscar Marin · FENS Forum 2024
Cortical neurons are specified during embryonic development but often only acquire their mature properties at relatively late stages of postnatal development. This delay in terminal differentiation is particularly prominent for fast-spiking parvalbumin-expressing (PV+) interneurons, which play critical roles in regulating the activity of the cerebral cortex. We found that the terminal differentiation of PV+ interneurons is triggered by neuronal activity and mediated by the transcriptional coactivator peroxisome proliferator-activated receptor-gamma coactivator 1-alpha (PGC-1a). Developmental l
ePoster · Neuroscience