Changes in neurotransmitter ATP/adenosine dynamics in the pathogenesis of metabolic liver diseases
Tomoko Tokumaru, Magdeline E. Carrasco Apolinario, Ryohei Umeda, Kenshiro Shikano, Hitoshi Teranishi, Kazunari Murakami, Reiko Hanada · FENS Forum 2024
ATP/Adenosine, a type of neurotransmitter, has recently attracted attention as damage-associated molecular patterns (DAMPs) and has been reported to play an important role in the induction of inflammation via inflammasome. On the other hand, there have been few reports on in vivo measurements of ATP and adenosine in the synaptic cleft and/or extracellular spaces.Generally, in vivo measurement of neurotransmitter content in the synaptic cleft and/or extracellular spaces has been performed mainly by invasive methods such as micro dialysis. However, recently, GPCR-activation-based (GRAB) sensor w
ePoster · Neuroscience