Role of the immune-neuroendocrine interplay during affective episodes and euthymia in bipolar patients: Searching a reliable biological signature of the disease
Alessandra Berry, Barbara Collacchi, Letizia Giona, Eleonora Tammaro, Vincenzo Coppola, Antonio Volpicelli, Francesca Cirulli, Mario Luciano · FENS Forum 2024
Bipolar disorder (BD) patients have shown increased circulating levels of pro-inflammatory cytokines and cortisol and decreased levels of Brain-Derived-Neurotrophic Factor (BDNF) suggesting that these mediators might be involved in the occurrence of affective episodes disrupting brain plasticity. Aim of the study was to assess variations in peripheral neuroendocrine and inflammatory markers during acute phases of the disease and euthymia as possible predictors of affective episodes and as a reliable signature of the disease. BD patients were enrolled during depressive or manic/hypomanic phases
ePoster · Neuroscience