Topic: metabolic substrates

Metabolic cost for the nervous system is very high due to the complexity of neuronal morphology and the processes to sustain neuronal transmission and synaptic plasticity. Cognitive functions underlying complex behaviors further increase brain energy demands. Despite the interest given to brain metabolism during the last years, how modification of metabolism might contribute to cognitive dysfunctions in brain disorders is not clear. Thus, we aim to identify the key metabolic pathways activated during complex cognitive functions. In this study, we will focus on metabolic pathways activated by d