Moderately high levels of plasma methylglyoxal are associated with lacunar infarcts – The Maastricht Study
Eline Berends, Simone J. P. M. Eussen, Walter H. Backes, Peter C. Dagnelie, Jacobus F. A. Jansen, Bastiaan E. de Galan, Marleen M. J. van Greevenbroek, Sebastian Köhler, Miranda Schram, Anke Wesselius, Robert J. van Oostenbrugge, Sébastien Foulquier, Casper G. Schalkwijk · FENS Forum 2024
Methylglyoxal (MGO), a by-product of glycolysis and major precursor in the formation of advanced glycation endproducts (AGEs), is increased during ageing and in diabetes and plays a role in peripheral microvascular dysfunction. Whether MGO affects the brain microvasculature is unknown. The aim of this study is to investigate whether higher plasma MGO concentrations are cross-sectionally associated with markers for cerebral small vessel disease (CSVD) and with cognitive impairment. In participants of the Maastricht Study, a population-based cohort study oversampled with type 2 diabetes (age=59.
ePoster · Neuroscience