A preclinical study to explore the glycotoxic impact of methylglyoxal on brain and gut health: Implications for Alzheimer's disease
Giulia Abate, Mariachiara Pucci, Emanuela Tirelli, Margherita Squillario, Gloria Bignotti, Marika Premoli, Serena Messali, Stefania Morandini, Giuseppina Maccarinelli, Moris Cadei, Andrea Mastinu, Sara Anna Bonini, Maurizio Memo, Vincenzo Villanacci, Simona Fiorentini, Daniela Uberti · FENS Forum 2024
Methylglyoxal (MGO), a potent dietary glycotoxin, serves as a key precursor to Advanced Glycation End products (AGEs), which have been linked to an increased risk of Alzheimer's disease (AD) exacerbation. Recognising the significance of lifestyle modifications, particularly nutritional interventions, in preventing brain deterioration, this study aimed to reveal the potentially harmful effects associated with a high-MGO diet on both brain and gut health.Our findings demonstrated MGO administration adversely affected working memory, inducing neuroinflammation and oxidative stress by modulating t
ePoster · Neuroscience