High and low frequencies of binge-like ethanol exposure in rats disrupt mGluR-LTD in hippocampus slices in a bidirectional way: Role of mTOR
Margot Debris, Chloé Deschamps, Mickaël Naassila, Olivier Pierrefiche · FENS Forum 2024
Binge drinking (BD) is characterized by consuming at least 70 g for men and 56 g for women of pure alcohol within two hours. Clinical studies examining the impact of BD on memory in young adults have revealed impairments across various types of memory (episodic, visuospatial, working memory...), although the frequency of BD often varies among studies. Preclinical research indicates that BD leads to the degradation of glutamate-dependent synaptic plasticity, the cellular mechanism of learning and memory in the hippocampus, including the metabotropic form of glutamatergic long-term synaptic depr
ePoster · Neuroscience