Topic: mGlu5R

Derived from the unique immune system of camelids, nanobodies are compact single-domainantibodies that have revolutionized the field of biomedical research. These miniaturized antibodies offer numerous advantages, including high specificity, stability, and ease of engineering. Interestingly, A2AR and mGlu5R form heteromers in the striatum, exhibiting synergistic transinhibition over striatal D2R signaling. 1 This oligomerization provides a unique pharmacological opportunity to explore whether the physical proximity of these receptors enables oligomer-dependent orthogonal targeting of counterpa