mGluR5-mediated deactivation of mPFC via somatostatin-positive interneuron in neuropathic pain mice
Mirae Jang, Jaegeon Lee, Seung Ha Kim, Sang Ho Yoon, Myoung-Hwan Kim, Sun Kwang Kim, Geehoon Chung, Sang Jeong Kim · FENS Forum 2024
Understanding the neurobiological alterations associated with neuropathic pain is crucial for treatment interventions, but the underlying mechanisms are not fully understood. Neuropathic pain causes many alterations in brain regions, including the medial prefrontal cortex (mPFC). The mPFC activity is decreased in the neuropathic pain state, which is associated with increased metabotropic glutamate receptor 5 (mGluR5) activity in this region. Here, we investigated whether mGluR5 inactivation restores neuropathic pain and, if so, how this inactivation affects local circuits in the mPFC. First, w
ePoster · Neuroscience