A physical impact to the cord leads to early massive depolarization sustained by chloride ions with transient reflex suppression
Atiyeh Mohammadshirazi, Giuliano Taccola · FENS Forum 2024
A physical impact to spinal cord causes a temporary motor areflexia below lesion during the clinical phase known as spinal shock. Spinal shock remains a quite mysterious phenomenon mainly due to the lack of a consistent preclinical model to study the early functional consequences of injury without the inevitable use of anesthesia, which in turn affects spinal excitability. In this study, our custom-made micro impactor provides a calibrated impact to the ventral surface of the thoracic spinal cord of in vitro neonatal rat preparations of entire CNS. Ventral root (VR) recordings continuously tra
ePoster · Neuroscience