Topic: microbiota dysbiosis

Maternal diet is a key determinant of later child’s metabolic and mental health outcomes. Human and/or animals consuming a western diet (WD), as compared to a healthy diet (HD), exhibit microbiota dysbiosis, low-grade inflammation, behavioral alterations and defects in the central reward circuit. Accordingly, epidemiological studies show that WD consumption during pregnancy is associated with adverse metabolic and mental health outcomes in offspring. We have developed a mouse model to study the impact of maternal WD on the offspring and challenged hypotheses related to dysbiosis, inflammation