Targeting the gut microbiota to ameliorate the effects of an early-life high-fat/high-sugar diet on eating behaviour in adolescence and adulthood
Cristina Cuesta-Marti, Eduardo Ponce España, Friederike Uhlig, Gerard Clarke, Siobhain M. O’Mahony, Harriët Schellekens · FENS Forum 2024
Early-life is a critical window in offspring development. An unhealthy diet during this period can negatively impact offspring metabolic function and eating behaviour later in life. Microbiota-targeted interventions hold promise for the treatment of aberrant functioning of eating behaviour. This study evaluates the impact of an early-life high-fat/high-sugar (HFHS) diet on eating behaviour later in life, and whether this can be attenuated by microbiota-targeted strategies.Male and female C57BL/6J mice were exposed to either control or HFHS diet from birth for 5 weeks. Afterwards, all mice rec
ePoster · Neuroscience