Topic: microcircuit analysis

Human brain function results from continuous activity flowing through specific cells, guided by specific synaptic arrangements. Therefore, determining the architecture and properties of functioning microcircuits is fundamental to understand the brain’s action. However, our current knowledge of human microcircuits is extremely limited, and relies heavily on assumptions from rodent research. Using tissue resected from 13 temporal lobe epilepsy patients, we perform multicellular patch-clamp based microcircuit analysis (n=80 recordings) to characterize synaptic connectivity in the human hippocampa