An optofluidic platform for interrogating chemosensory behavior and brainwide neural representation
Kwun Hei Samuel Sy, Yu Hu, Danny C. W. Chan, Roy C. H. Chan, Jing Lyu, Zhongqi Li, Kenneth K. Y. Wong, Chung Hang Jonathan Choi, Vincent C. T. Mok, Hei-Ming Lai, Owen Randlett, Ho Ko · COSYNE 2023
Studying chemosensory processing desires precise chemical cue presentation, behavioral response monitoring, and large-scale neuronal activity recording. Larval zebrafish are especially attractive vertebrates for such study. Behavioral assays and imaging systems that can achieve the necessary spatial precision for chemical delivery is an important pre-requisite for data interpretation. Here we present Fish-on-Chips, a set of optofluidic tools for highly-controlled chemical delivery while simultaneously imaging behavioral outputs and whole-brain neuronal activities at cellular resolution in larv
Sun, Mar 12, 2023