Topic: microglia cells

Neuroinflammation is a fundamental element of many neurodegenerative disorders. Activation of astrocytes and microglia cells leads to a release of cytokines and reactive oxygen species followed by leakage of the blood-brain barrier and neurotoxicity. Transient neuroinflammation is understood to be largely protective, chronic neuroinflammation, however, contributes to the pathology of Alzheimer’s disease, traumatic brain injury, and many more. In this study, we focus on the aspect of cytokine-induced neuroinflammation in human microglia cells and especially in astrocytes, since many studies on