Treatment of NP106-expressing adeno-associated virus in microglia-mediated Aβ clearance and behavioral deficits in APP/PS1 mice
Yu-Ling Gan, Ying-Ting Hsu, Jung-Tsung Hsueh, Feng-Shiun Shie · FENS Forum 2024
Aβ plays an important role in the pathogenesis of Alzheimer’s disease (AD), and passive immunotherapy targeting Aβ has emerged as a promising treatment approach. However, the administration of antibody drugs is limited due to many concerns. Therefore, using adeno-associated virus (AAV) gene therapy to deliver antibody drugs may introduce innovative treatment regimens for AD. We have previously shown that NP106, a novel anti-Aβ antibody, exhibits multiple therapeutic benefits for ameliorating brain Aβ burden and cognitive impairment in APP/PS1 mouse model of AD. In this study, we developed an N
ePoster · Neuroscience