Cannabidiol modulated compensation of radiation-induced alterations in hippocampal synaptic plasticity and neuronal function
Markus Ballmann, Lisa Bauer, Bayan Alkotub, Gabriele Multhoff, Gerhard Rammes · FENS Forum 2024
Background: Radiotherapy is a common treatment for brain tumors, yet it often leads to cognitive decline. Past understanding suggested this damage was irreversible due to DNA damage and cell death. However, recent studies propose that it may be reversible, as it affects active cells. Scientists focus on hippocampal activity, crucial for learning and memory, to explore this. Radiation is thought to decrease neurogenesis and increase neuroinflammation in the hippocampus. Anti-inflammatory drugs are suggested as a potential solution to mitigate cognitive decline from radiation.Aims: Analyzing the
ePoster · Neuroscience