A novel perspective: Early-life stress at the origin of AD-related mitochondrial dysfunctions
Sanne Roovers, Silvie R. Ruigrok, Janssen M. Kotah, Mark Verheijen, Susanne R. de Rooij, Aniko Korosi · FENS Forum 2024
Alzheimer’s disease (AD) is a highly prevalent age-related neurological disorder, characterized by progressive cognitive decline and accumulation of neuropathological hallmarks in various brain regions. Emerging research highlights early-life stress (ELS) as a significant risk factor in its pathogenesis. We and others have demonstrated in preclinical models that ELS exacerbates both pathology of AD and glial response to amyloid-overexpression. Recently, we demonstrated possible convergence of ELS, AD and mitochondrial dysfunctions, utilizing proteomic analysis of synaptosomes. Seeking to unde
ePoster · Neuroscience