Topic: microglial defensive functions

Neuroinflammation is considered to play a crucial role in Alzheimer’s disease (AD) nowadays, placing glial cells on the front page. Although several evidences point to the decline of microglial defensive functions, the contribution of these cells in AD progression is still unknown. In recent years, microglial depletion approaches in mouse models have provided new insights into the role of these cells in physiological and pathological conditions (doi: 10.4103/1673-5374.308078). In this regard, our group has generated a genetic depletion AD model that allows the targeting of microglia in a cell-