Topic: microglial density

Numerous cohort studies on the “Dutch famine,” in which pregnant women were exposed to a severe food shortage, have indicated a linkage between famine exposure during early pregnancy and a heightened risk of schizophrenia (SCZ) onset among offspring. These findings endorsed the Developmental Origins of Health and Disease (DOHaD) theory. However, the underlying mechanisms remain unclear. In this study, we exposed fertilized mice to a 16-hour overnight fast on embryonic day 1 (E1), E3, and E5, to mimic early pregnancy famine exposure. Offspring were examined for phenotypes in adulthood. Using 10

Anorexia nervosa (AN) is a serious eating disorder prevalently widespread in female subjects, characterized by a severe restriction of caloric intake, fear of becoming fat, dysmorphophobia and hyperactivity (DSM–5). Nowadays growing evidence shed light about the involvement of immunoinflammatory pathways in AN, considering the rise in the peripheral levels of pro-inflammatory cytokines in patients (Solmi et al., 2015). Furthermore, neuroinflammation may be an additional characteristic of AN (Rahimian et al., 2021), since it has been observed in other psychiatric disorders. The Activity-Based A