Topic: microglial inflammation

The generation of new neurons in the hippocampus, known as adult hippocampal neurogenesis (AHN), is a distinctive plastic process that plays an important role in mechanisms of learning, memory, and mood regulation. Various factors intricately regulate the proliferation, survival, and differentiation of newborn neurons, shaping the neurogenic niche. Microglia and astrocytes, prominent niche components, actively regulate AHN. Microglia, acting as vigilant immune sentinels, shape AHN through direct interaction with immature neurons and the release of critical soluble factors. Similarly, astrocyte