The steroid sulfatase inhibitor STX64 improves mice cognitive deficiencies associated with aging
Juan Antonio Fernández Cabrera, Inés Sánchez Romero, José Manuel Hernández Curiel, M Mercedes Pérez Jiménez, Manuel Jesús Muñoz Ruiz, Ángel Manuel Carrión Rodríguez · FENS Forum 2024
Aging produces in brain a progressive oxidative process and neuroinflammation that deteriorates cognition. These brain dysfunctions provoke high economic and social costs to developed societies. For this reason, the search for treatments to prevent cognitive deficits associated with aging is a priority. Previous results suggest that STX64, a steroid sulfatase (STS) inhibitor, improves cognition in neurodegenerative diseases. In this work, we have designed cellular (immunohistochemistry), molecular (qPCRs with primers of inflammatory markers and cellular populations) and behaviour (mainly, obje
ePoster · Neuroscience