Topic: microglial spatial organization

Microglia cover the whole brain parenchyma, where each microglia cell occupies a fixed position and, through its projections, surveils its own territory (Kierdorf and Prinz, 2017). Genetic (Bruttger et al., 2015) or pharmacologic (Elmore et al., 2014) partial ablation of adult microglia is followed by a recovery of their number and coverage of the brain parenchyma, supporting a fundamental role of microglial spatial organization in local surveillance (Nimmerjahn et al., 2005). Neurological disorders, particularly Alzheimer’s Disease (AD), associate with dysfunctional microglia, which cluster a