ePoster · Neuroscience
In vitro analysis of drug-induced neuron degeneration by morphological deep learning on a novel microphysiological system
Ikuro Suzuki, Xiaobo Han, Kazuki Matsuda, Naoki Matsuda, Makoto Yamanaka · FENS Forum 2024
Microphysiological system (MPS) is an in vitro culture technology that reproduces the physiological microenvironment and functionality of humans, and is expected to be applied for evaluating drug efficiency/toxicity. In this study, we developed a MPS for structured culture of human iPSC-derived neurons, then predict drug-induced neurotoxicity by morphological analysis.COP (Cyclo olefin polymer), which has excellent observability and low drug adsorption, is used as the material of the MPS. Successful culture of human iPSC-derived sensory neurons and human iPSC-derived cortical neurons with sepa