Functional and microstructural MRI substrates of conserved memory in healthy ageing
Elena Espinós Soler, Egoa Ugarte Pérez, Antonio Cerdán Cerdá, Patricia Martínez Tazo, Mohamed Kotb Selim, Santiago Canals, Silvia De Santis · FENS Forum 2024
The brain parenchyma undergoes several structural changes throughout life that significantly impact on its physiology, and are reflected in changes in cognitive abilities. The aim of this healthy ageing study was to investigate how age-related microstructural alterations affect the degree of preserved cognition in the elderly. We sought to identify brain region- and age-specific patterns that contribute to the physiological decline in cognition. To this end, we compared behavioral and microstructural MRI biomarkers in adult (6 months) and old (1.5 years) Wistar rats. Additionally, we analyzed
ePoster · Neuroscience