Optimizing serum-free neuronal differentiation of SH-SY5Y cells: Implications for Alzheimer's disease therapy
Ihor Kozlov, Aleksandr Deviatov, Viswanath Das · FENS Forum 2024
Dementia, particularly Alzheimer's disease (AD), is a significant health challenge in Europe, characterized by tauopathy and the progressive loss of cholinergic neurons in the basal forebrain. Despite extensive research, effective treatments remain elusive. Utilizing neuroblastoma cells like SH-SY5Y offers a promising avenue to mimic neuronal phenotypes in vitro, aiding in disease mechanism exploration and therapy testing. However, establishing reliable differentiation protocols, especially under serum-free conditions, is imperative.This study aims to refine differentiation protocols and evalu
ePoster · Neuroscience