Topic: microtubule-associated protein tau (MAP-Tau)

During the course of hibernation a rapid and reversible retraction and remodeling of dendrites and spines occurs in the brain of small hibernating mammals. Similar plasticity is also observed in hypothermic mice and rats, suggesting that the phenomenon is not exclusively regulated by hibernation-specific gene expression. While plasticity mechanisms during hibernation have mainly been studied in the hippocampus, the brain wide expression of a reversible and temperature-dependent phosphorylation of microtubule-associated protein tau (MAP-Tau), in both hibernating animals and non-hibernators, fur