Gut bacterial toxin further enhances blood-brain barrier alterations in a progressive mouse model of Parkinson’s disease
Kristina Lau, Lisa Porschen, Anna-Sophia Hartke, Christopher Käufer, Birthe Gericke, Franziska Richter · FENS Forum 2024
There is increasing evidence for dysfunction of blood-brain barrier (BBB) to play a critical role in the pathological mechanisms and progression of Parkinson’s disease (PD). PD-related pathology such as alpha-synuclein (aSyn) accumulation potentially affects the integrity of the BBB starting at an early disease stage. This could result in a self-perpetuating pathophysiology of inflammation and BBB alteration, which contributes to neurodegeneration.In our initial study, we described microvascular changes during disease progression in a mouse model with overexpression of human aSyn (Thy1-aSyn, l
ePoster · Neuroscience