Cerebral consequences of hypertension and NEMO deletion in brain endothelial cells in mice
Marietta Zille, Sarah Grabner, Floradel Bürgel, Frederike Heiden, Katja Grau, Markus Schwaninger · FENS Forum 2024
Hypertension (HT) is a leading risk factor for brain injury. Endothelial dysfunction can be observed in HT and may result in blood-brain barrier (BBB) impairment, which leads to neuroinflammation. We aimed to assess the contribution of brain endothelial dysfunction to HT-induced brain injury in mice. We induced the loss of NEMO, the essential modulator of nuclear factor-κB, in brain endothelial cells (NemobeKO). Control mice received tamoxifen (NemoFl). HT was induced by chronic infusion of angiotensin II and nitric oxide synthase inhibitor in the drinking water for 28 days. After 7 days, HT m
ePoster · Neuroscience