NVU alterations explain motivational deficits in a murine model of chronic distress
Lidia Cabeza Alvarez, Damien Mor, Bahrie Ramadan, Guillaume Benhora-Chabeaux, Christophe Houdayer, Emmanuel Haffen, Yvan Peterschmitt, Adeline Etievant, Fanchon Bourasset · FENS Forum 2024
The neurovascular unit (NVU) represents the structural and functional relationship between the neural tissue and the blood. Neurovascular dysfunction has been highlighted in neuropsychiatric afflictions, but it is still unclear whether it is a cause or a consequence of the pathology. Studying how NVU components associate might clarify its role on the emergence of emotional-cognitive dysfunction. This study aims at investigating whether the development of depressive-related loss of motivation is grounded on NVU modifications impacting the permeability of the blood-brain barrier (BBB) and in par
ePoster · Neuroscience