Dorsal raphe nuclei/ventrolateral periaqueductal grey and cerebellar fastigial nucleus interactions modulate danger response during fear learning
Julie Urrutia, Clément Léna, Daniela Popa · FENS Forum 2024
Fear learning and extinction are crucial for survival and lead to disease, if impaired. Recently, it has been demonstrated that the cerebellum is bidirectionally controlling fear learning via the fastigial nucleus (FN) to ventrolateral periaqueductal grey (vlPAG) pathway in rodents (Frontera et al., 2020, Lawrenson et al., 2022). The mechanisms of the cerebellar influence on fear learning still need to be elucidated. Using a combined anterograde/retrograde viral tracing strategy, we targeted a dorsal raphe nuclei (DRN)/vlPAG pathway that projects on the FN. In extracellular recordings during a
ePoster · Neuroscience