Mechanisms of facilitation of cortical spreading depression in a genetic mouse model of migraine with a gain-of-function mutation in CaV2.1 channels
Marina Vitale, Angelita Tottene, Maral Zarin Zadeh, Daniela Pietrobon · FENS Forum 2024
Cortical spreading depression (CSD) is the neurophysiological correlate of migraine aura and a trigger of migraine pain mechanisms. The mechanisms of initiation of CSD in migraineurs are unknown. Insights into these mechanisms can be obtained by studying the mechanisms of facilitation of CSD initiation in genetic mouse models of the disease. Here, we investigated these mechanisms in knock-in mice carrying a mutation in cacna1a causing familial hemiplegic migraine (FHM1 mice). High KCl puffs of increasing duration up to the threshold duration eliciting a CSD were applied on layer 2/3 of cerebra
ePoster · Neuroscience