Blood-brain barrier on-a-chip to study compound-induced disruption
Rumaisha Annida, Tania Fowke, Arnaud Nicolas, Flora Kovacs, Arya Lekshmi Nair, Maria Pontier, Nienke Wevers · FENS Forum 2024
The vasculature of the brain is made up of specialized endothelial cells that form a tight blood-brain barrier (BBB). Weakening of the junctional proteins can lead to BBB disruption. This can have detrimental effects on patients’ health, as the homeostatic environment of the brain becomes compromised.The MIMETAS OrganoPlate® is a microfluidic platform that enables perfused, 3D culture of up to 96 tissues in parallel in a membrane-free manner. The microfluidic channels allow growth of perfused tubular endothelial structures. Furthermore, the system allows for automation, enabling higher through
ePoster · Neuroscience