Serum irisin levels positively correlate with neuropsychological scores in patients with dementia and could be a potential biomarker of Alzheimer’s disease
Patrizia Pignataro, Manuela Dicarlo, Chiara Zecca, Maria Teresa Dell’Abate, Marco Filardi, Daniele Urso, Valentina Gnoni, Alessia Giugno, Francesco Borlizzi, Roberta Zerlotin, Angela Oranger, Graziana Colaianni, Silvia Colucci, Giancarlo Logroscino, Maria Grano · FENS Forum 2024
Dementia is a prevalent and, based on severity, disabling neurocognitive disorder that primarily affects people older than 65 years of age. There is an increasingly emerging need to identify specific markers of dementia for interventions before disease progression. Irisin is a myokine produced during exercise with multiple effects on various organs, including a neuroprotective role on brain. Here, we investigated the involvement of irisin in patients with dementia biologically classified according to the Amyloid-β-Tau-Neurodegeneration classification system. Serum and cerebrospinal fluid (CSF)
ePoster · Neuroscience