Topic: miniendoscopic calcium imaging

To flexibly update behavior in response to a sudden change in outcome of previously learned cues and actions, neural activity in the orbitofrontal cortex (OFC) must be updated. Novelty activates the locus coeruleus (LC), a group of cells in the brainstem that release the neurotransmitter norepinephrine (NE) throughout the brain. NE release may drive behavioral flexibility by facilitating the reorganization of neural activity in target brain areas, including the OFC. To test this hypothesis, mice were assessed in a T-maze reversal learning task, which requires subjects to reverse a previo