Differential roles for dysregulated microRNAs after a peripheral nerve injury in neuropathic pain or nerve regeneration
Theodora Kalpachidou, Maximilian Zeidler, Viktor Lang, Maria Peteinareli, Laura Castaldi, Paul Heppenstall, Hermona Soreq, Kai Kummer, Michaela Kress · FENS Forum 2024
microRNAs (miRNAs) are small, non-coding RNAs involved in all processes in health and disease, including neuropathic pain and neuroregeneration. Upon peripheral nerve injury (PNI), dorsal root ganglia (DRG) neurons exhibit increased excitability and altered signaling, leading to dysregulation of their transcriptomic profiles indicative of neuropathic pain and axono-regenerative processes. The complexity of these neuronal responses makes distinguishing between the mechanisms involved in neuroregeneration and neuropathy highly challenging. To elucidate the role of miRNAs in these processes, we u
ePoster · Neuroscience